Abstract
Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication, nuclear assembly and nuclear positioning. Over the past few years, interest in the lamins has increased because of the identification of at least 12 distinct human diseases associated with mutations in the LMNA gene, which encodes A-type lamins. These diseases, collectively termed laminopathies, affect muscle, adipose, bone, nerve and skin cells and range from muscular dystrophies to accelerated aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-341 |
| Number of pages | 7 |
| Journal | Current Opinion in Cell Biology |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2006 |
Funding
We thank Ayelet Margalit, Shai Melcer and Mati Mann for comments. The Gruenbaum lab is funded by grants from the Israel Science Foundation (ISF), The Israel Ministry of Health, the USA-Israel Binational foundation (BSF), the Cooperation Program in Cancer Research of the Deutsches Krebsforschungszentrum (DKFZ) and Israel's Ministry of Science and Technology (MOST). The Goldman lab is funded by the NIA, the NCI, the MDA, the Progeria Research Foundation and an Ellison Senior Scholar Award. The Adams lab is funded by the NIA. Thomas Dechat is funded by an Erwin Schroedinger fellowship of the Austrian Science Foundation.
ASJC Scopus subject areas
- Cell Biology
