Nuclear lamins, diseases and aging

Anna Mattout*, Thomas Dechat, Stephen A. Adam, Robert D. Goldman, Yosef Gruenbaum

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations

Abstract

Nuclear lamins are type V intermediate filament proteins. They are the major building blocks of the peripheral nuclear lamina, a complex meshwork of proteins underlying the inner nuclear membrane. In addition to providing nuclear shape and mechanical stability, they are required for chromatin organization, transcription regulation, DNA replication, nuclear assembly and nuclear positioning. Over the past few years, interest in the lamins has increased because of the identification of at least 12 distinct human diseases associated with mutations in the LMNA gene, which encodes A-type lamins. These diseases, collectively termed laminopathies, affect muscle, adipose, bone, nerve and skin cells and range from muscular dystrophies to accelerated aging.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume18
Issue number3
DOIs
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Nuclear lamins, diseases and aging'. Together they form a unique fingerprint.

Cite this