Nuclear lamins: Major factors in the structural organization and function of the nucleus and chromatin

Thomas Dechat, Katrin Pfleghaar, Kaushik Sengupta, Takeshi Shimi, Dale K. Shumaker, Liliana Solimando, Robert D. Goldman

Research output: Contribution to journalReview articlepeer-review

605 Scopus citations

Abstract

Over the past few years it has become evident that the intermediate filament proteins, the types A and B nuclear lamins, not only provide a structural framework for the nucleus, but are also essential for many aspects of normal nuclear function. Insights into lamin-related functions have been derived from studies of the remarkably large number of disease-causing mutations in the human lamin A gene. This review provides an up-to-date overview of the functions of nuclear lamins, emphasizing their roles in epigenetics, chromatin organization, DNA replication, transcription, and DNA repair. In addition, we discuss recent evidence supporting the importance of lamins in viral infections.

Original languageEnglish (US)
Pages (from-to)832-853
Number of pages22
JournalGenes and Development
Volume22
Issue number7
DOIs
StatePublished - Apr 1 2008

Keywords

  • Chromatin
  • Epigenetics
  • Laminopathies
  • Lamins
  • Nuclear architecture
  • Viruses

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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