Nuclear signaling from cadherin adhesion complexes

Pierre D. McCrea*, Meghan T. Maher, Cara Gottardi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

38 Citations (Scopus)

Abstract

The arrival of multicellularity in evolution facilitated cell-cell signaling in conjunction with adhesion. As the ectodomains of cadherins interact with each other directly in trans (as well as in cis), spanning the plasma membrane and associating with multiple other entities, cadherins enable the transduction of "outside-in" or "inside-out" signals. We focus this review on signals that originate from the larger family of cadherins that are inwardly directed to the nucleus, and thus have roles in gene control or nuclear structure-function. The nature of cadherin complexes varies considerably depending on the type of cadherin and its context, and we will address some of these variables for classical cadherins versus other family members. Substantial but still fragmentary progress has been made in understanding the signaling mediators used by varied cadherin complexes to coordinate the state of cell-cell adhesion with gene expression. Evidence that cadherin intracellular binding partners also localize to the nucleus is a major point of interest. In some models, catenins show reduced binding to cadherin cytoplasmic tails favoring their engagement in gene control. When bound, cadherins may serve as stoichiometric competitors of nuclear signals. Cadherins also directly or indirectly affect numerous signaling pathways (e.g., Wnt, receptor tyrosine kinase, Hippo, NFκB, and JAK/STAT), enabling cell-cell contacts to touch upon multiple biological outcomes in embryonic development and tissue homeostasis.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages129-196
Number of pages68
DOIs
StatePublished - Jan 1 2015

Publication series

NameCurrent Topics in Developmental Biology
Volume112
ISSN (Print)0070-2153

Fingerprint

Cadherins
Wnt Receptors
Catenins
Cell Adhesion
Protein-Tyrosine Kinases
Genes
Embryonic Development
Homeostasis
Cell Membrane
Gene Expression

Keywords

  • Atypical cadherins
  • Desmosomal cadherins
  • Hippo signaling
  • Outside-in signaling
  • Protocadherins
  • RTK signaling
  • Wnt signaling

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

McCrea, P. D., Maher, M. T., & Gottardi, C. (2015). Nuclear signaling from cadherin adhesion complexes. In Current Topics in Developmental Biology (pp. 129-196). (Current Topics in Developmental Biology; Vol. 112). Academic Press Inc.. https://doi.org/10.1016/bs.ctdb.2014.11.018
McCrea, Pierre D. ; Maher, Meghan T. ; Gottardi, Cara. / Nuclear signaling from cadherin adhesion complexes. Current Topics in Developmental Biology. Academic Press Inc., 2015. pp. 129-196 (Current Topics in Developmental Biology).
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McCrea, PD, Maher, MT & Gottardi, C 2015, Nuclear signaling from cadherin adhesion complexes. in Current Topics in Developmental Biology. Current Topics in Developmental Biology, vol. 112, Academic Press Inc., pp. 129-196. https://doi.org/10.1016/bs.ctdb.2014.11.018

Nuclear signaling from cadherin adhesion complexes. / McCrea, Pierre D.; Maher, Meghan T.; Gottardi, Cara.

Current Topics in Developmental Biology. Academic Press Inc., 2015. p. 129-196 (Current Topics in Developmental Biology; Vol. 112).

Research output: Chapter in Book/Report/Conference proceedingChapter

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McCrea PD, Maher MT, Gottardi C. Nuclear signaling from cadherin adhesion complexes. In Current Topics in Developmental Biology. Academic Press Inc. 2015. p. 129-196. (Current Topics in Developmental Biology). https://doi.org/10.1016/bs.ctdb.2014.11.018