Nuclear signaling from cadherin adhesion complexes

Pierre D. McCrea*, Meghan T. Maher, Cara J. Gottardi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

46 Scopus citations

Abstract

The arrival of multicellularity in evolution facilitated cell-cell signaling in conjunction with adhesion. As the ectodomains of cadherins interact with each other directly in trans (as well as in cis), spanning the plasma membrane and associating with multiple other entities, cadherins enable the transduction of "outside-in" or "inside-out" signals. We focus this review on signals that originate from the larger family of cadherins that are inwardly directed to the nucleus, and thus have roles in gene control or nuclear structure-function. The nature of cadherin complexes varies considerably depending on the type of cadherin and its context, and we will address some of these variables for classical cadherins versus other family members. Substantial but still fragmentary progress has been made in understanding the signaling mediators used by varied cadherin complexes to coordinate the state of cell-cell adhesion with gene expression. Evidence that cadherin intracellular binding partners also localize to the nucleus is a major point of interest. In some models, catenins show reduced binding to cadherin cytoplasmic tails favoring their engagement in gene control. When bound, cadherins may serve as stoichiometric competitors of nuclear signals. Cadherins also directly or indirectly affect numerous signaling pathways (e.g., Wnt, receptor tyrosine kinase, Hippo, NFκB, and JAK/STAT), enabling cell-cell contacts to touch upon multiple biological outcomes in embryonic development and tissue homeostasis.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc
Pages129-196
Number of pages68
DOIs
StatePublished - 2015

Publication series

NameCurrent Topics in Developmental Biology
Volume112
ISSN (Print)0070-2153

Keywords

  • Atypical cadherins
  • Desmosomal cadherins
  • Hippo signaling
  • Outside-in signaling
  • Protocadherins
  • RTK signaling
  • Wnt signaling

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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