Nuclear subdomains and cancer

Kendra L. Cann, Sui Huang, Graham Dellaire*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer develops when genetic changes, such as the activation of oncogenes and inactivation of tumour suppressors, allow a cell to escape the normal growth and proliferation restrictions. These functional changes ultimately result in structural alterations at both the nuclear and cellular levels. As such, cell morphology and biological marker expression are some of the main criteria in tumour pathology for diagnosis and prognosis. The development of advanced microscopy techniques has provided a much more detailed map of the nuclear landscape, and because of this, structural changes in subnuclear bodies induced during oncogenesis can be readily visualized. This type of analysis has identified novel cancer biomarkers in the form of nuclear structures associated with malignancy, such as the perinucleolar compartment (PNC). It has also allowed a much more detailed examination of nuclear body function, which has provided novel mechanisms and regulators of tumour suppression and oncogenesis. This chapter will focus on three of the most important subnuclear domains for cancer biology: promyelocytic leukemia nuclear bodies (PML NBs), the nucleolus, and the perinucleolar compartment (PNC).

Original languageEnglish (US)
Title of host publicationAdvances in Nuclear Architecture
PublisherSpringer Netherlands
Pages1-58
Number of pages58
ISBN (Electronic)9789048198993
ISBN (Print)9789048198986
DOIs
StatePublished - Jan 1 2011

Keywords

  • Biomarkers
  • Cancer
  • Nucleolus
  • Oncogene
  • Perinucleolar compartment (PNC)
  • Promyelocytic leukemia bodies (PML NBs)
  • Tumour suppressor
  • p53

ASJC Scopus subject areas

  • Medicine(all)

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