Nucleation of Multiple Buckled Structures in Intertwined DNA Double Helices

Sumitabha Brahmachari, Kathryn H. Gunn, Rebecca D. Giuntoli, Alfonso Mondragón, John F. Marko

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We study the statistical-mechanical properties of intertwined double-helical DNAs (DNA braids). In magnetic tweezers experiments, we find that torsionally stressed stretched braids supercoil via an abrupt buckling transition, which is associated with the nucleation of a braid end loop, and that the buckled braid is characterized by a proliferation of multiple domains. Differences between the mechanics of DNA braids and supercoiled single DNAs can be understood as an effect of the increased bulkiness in the structure of the former. The experimental results are in accord with the predictions of a statistical-mechanical model.

Original languageEnglish (US)
Article number188103
JournalPhysical review letters
Volume119
Issue number18
DOIs
StatePublished - Oct 31 2017

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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