Nucleic acid-gold nanoparticle conjugates as mimics of microRNA

Liangliang Hao, Pinal C. Patel, Ali H. Alhasan, David A. Giljohann, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Novel conjugates of gold nanoparticles functionalized with synthetic microRNAs can enter cells without the aid of cationic co-carriers and mimic the function of endogenous microRNAs. These conjugates can regulate multiple proteins through interactions with the 3′ untranslated region of the target messenger RNA and control cell behavior. The conjugates are promising new tools for studying microRNA function and are candidates for microRNA replacement therapies.

Original languageEnglish (US)
Pages (from-to)3158-3162
Number of pages5
JournalSmall
Volume7
Issue number22
DOIs
StatePublished - Nov 18 2011

Keywords

  • cancer therapy
  • gene regulation
  • gold nanoparticles
  • microRNA
  • siRNA

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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