Nucleic acid mediated electron transfer

Thomas J Meade (Inventor), Jon F. Kayyem (Inventor), Scott E. Fraser (Inventor)

Research output: Patent


The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of the nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes. Hybridization assays employing these complexes are disclosed.
Original languageEnglish (US)
Patent number5591578
Filing date12/10/93
StatePublished - Jan 7 1997


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