Nucleic acid-metal organic framework (MOF) nanoparticle conjugates

William Morris, William E. Briley, Evelyn Auyeung, Maria D. Cabezas, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticle

229 Scopus citations


Nanoparticles of a metal-organic framework (MOF), UiO-66-N3 (Zr6O4OH4(C8H3O 4-N3)6), were synthesized. The surface of the MOF was covalently functionalized with oligonucleotides, utilizing a strain promoted click reaction between DNA appended with dibenzylcyclooctyne and azide-functionalized UiO-66-N3 to create the first MOF nanoparticle-nucleic acid conjugates. The structure of the framework was preserved throughout the chemical transformation, and the surface coverage of DNA was quantified. Due to the small pore sizes, the particles are only modified on their surfaces. When dispersed in aqueous NaCl, they exhibit increased stability and enhanced cellular uptake when compared with unfunctionalized MOF particles of comparable size.

Original languageEnglish (US)
Pages (from-to)7261-7264
Number of pages4
JournalJournal of the American Chemical Society
Issue number20
StatePublished - May 21 2014

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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