Nucleocytoplasmic functions of the PDZ-LIM protein family: New insights into organ development

Jennifer Krcmery, Troy Camarata, Andre Kulisz, Hans Georg Simon*

*Corresponding author for this work

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Recent work on the PDZ-LIM protein family has revealed that it has important activities at the cellular level, mediating signals between the nucleus and the cytoskeleton, with significant impact on organ development. We review and integrate current knowledge about the PDZ-LIM protein family and propose a new functional role, sequestering nuclear factors in the cytoplasm. Characterized by their PDZ and LIM domains, the PDZ-LIM family is comprised of evolutionarily conserved proteins found throughout the animal kingdom, from worms to humans. Combining two functional domains in one protein, PDZ-LIM proteins have wide-ranging and multi-compartmental cell functions during development and homeostasis. In contrast, misregulation can lead to cancer formation and progression. New emerging roles include interactions with integrins, T-box transcription factors, and receptor tyrosine kinases. Facilitating the assembly of protein complexes, PDZ-LIM proteins can act as signal modulators, influence actin dynamics, regulate cell architecture, and control gene transcription.

Original languageEnglish (US)
Pages (from-to)100-108
Number of pages9
JournalBioEssays
Volume32
Issue number2
DOIs
StatePublished - 2010

Keywords

  • Actin cytoskeleton
  • Organogenesis
  • PDZ-LIM
  • Scaffold
  • T-box

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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