Nucleophagy: A New Look at Past Observations

Han Peng, Robert M. Lavker*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

6 Scopus citations


Keratinization of the stratum corneum involves a highly choreographed sequence of events in which granular cells lose their nuclei and become desiccated corneocytes. Akinduro et al. detail the molecular machinery underlying removal of the nucleus (nucleophagy) during the final stages of keratinization. They provide evidence that nucleophagy is induced when the keratinocytes differentiate and that failure in the initiation of nucleophagy is associated with parakeratosis.

Original languageEnglish (US)
Pages (from-to)1316-1318
Number of pages3
JournalJournal of Investigative Dermatology
Issue number7
StatePublished - Jul 1 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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