Nucleophilic perfluoroalkylation of nitrones

Derek W. Nelson*, Regina A. Easley, Beniamin N V Pintea

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


New methods for perfluoroalkylation of carbon-nitrogen double bonds have been developed. Addition of (trifluoromethyl)trimethylsilane (TMSCF3) to α,N-diarylnitrones produced α series of α-(trifluoromethyl)-N hydroxyl amines protected as their O-trimethylsilyl derivatives. An alternate procedure using pentafluoroethyllithium (F5C2L1) and chlorotrimethylsilane (TMSCI) afforded O-trimethylsilyl-α-(pentafluoroethyl)-N-hydroxyl amines.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalTetrahedron Letters
Issue number1
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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