Nucleosome switches

David J. Schwab; Robijn F. Bruinsma; Joseph Rudnick; Jonathan Widom

doi:10.1103/PhysRevLett.100.228105

Nucleosome switches

David J. Schwab, Robijn F. Bruinsma, Joseph Rudnick, Jonathan Widom

Physics and Astronomy

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a localized, first-order transition. The location of the nucleosome switches shows a strong correlation with the location of gene-regulation regions.

Original language	English (US)
Article number	228105
Journal	Physical review letters
Volume	100
Issue number	22
DOIs	https://doi.org/10.1103/PhysRevLett.100.228105
State	Published - Jun 6 2008

ASJC Scopus subject areas

General Physics and Astronomy

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10.1103/PhysRevLett.100.228105

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title = "Nucleosome switches",

abstract = "We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a localized, first-order transition. The location of the nucleosome switches shows a strong correlation with the location of gene-regulation regions.",

author = "Schwab, {David J.} and Bruinsma, {Robijn F.} and Joseph Rudnick and Jonathan Widom",

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AB - We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a localized, first-order transition. The location of the nucleosome switches shows a strong correlation with the location of gene-regulation regions.

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Nucleosome switches

Abstract

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