Nucleosome switches

David J. Schwab, Robijn F. Bruinsma, Joseph Rudnick, Jonathan Widom

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a localized, first-order transition. The location of the nucleosome switches shows a strong correlation with the location of gene-regulation regions.

Original languageEnglish (US)
Article number228105
JournalPhysical review letters
Issue number22
StatePublished - Jun 6 2008

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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