Nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79: Maintenance of a second large open reading frame

Scott W. Hiebert; Mark A. Williams; Robert A. Lamb

doi:10.1016/0042-6822(86)90237-0

Nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79: Maintenance of a second large open reading frame

Scott W. Hiebert, Mark A. Williams, Robert A. Lamb^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79 has been determined. The deduced amino acid sequence of the M₁ protein indicates that it contains 248 amino acids of which 243 are identical in the B/Lee/40 M, protein. A second overlapping open reading frame with a maximum coding region of 195 amino acids has also been maintained in the 39 years separating the two isolates. The deduced amino acid sequence of the second coding region displays 86% homology with the comparable B/Lee/40 sequence (27 changes). The conservation of the second open reading frame suggests that this region is important in the replicative cycle of influenza B viruses.

Original language	English (US)
Pages (from-to)	747-751
Number of pages	5
Journal	Virology
Volume	155
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(86)90237-0
State	Published - Dec 1986

ASJC Scopus subject areas

Virology

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@article{f85672ecc91c439a83bdef7ae8077f1d,

title = "Nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79: Maintenance of a second large open reading frame",

abstract = "The nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79 has been determined. The deduced amino acid sequence of the M1 protein indicates that it contains 248 amino acids of which 243 are identical in the B/Lee/40 M, protein. A second overlapping open reading frame with a maximum coding region of 195 amino acids has also been maintained in the 39 years separating the two isolates. The deduced amino acid sequence of the second coding region displays 86% homology with the comparable B/Lee/40 sequence (27 changes). The conservation of the second open reading frame suggests that this region is important in the replicative cycle of influenza B viruses.",

author = "Hiebert, {Scott W.} and Williams, {Mark A.} and Lamb, {Robert A.}",

note = "Funding Information: We thank Dr. Debi Nayak for making available a cDNA clone to B/Sing/222179 RNA segment 7. This research was supported by Public Health Service Awards AI-20201 and AI-23173 from the National Institute of Allergy and Infectious Diseases. R.A.L. is an Established Investigator of the American Heart Association.",

year = "1986",

month = dec,

doi = "10.1016/0042-6822(86)90237-0",

language = "English (US)",

volume = "155",

pages = "747--751",

journal = "Virology",

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T1 - Nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79

T2 - Maintenance of a second large open reading frame

AU - Hiebert, Scott W.

AU - Williams, Mark A.

AU - Lamb, Robert A.

N1 - Funding Information: We thank Dr. Debi Nayak for making available a cDNA clone to B/Sing/222179 RNA segment 7. This research was supported by Public Health Service Awards AI-20201 and AI-23173 from the National Institute of Allergy and Infectious Diseases. R.A.L. is an Established Investigator of the American Heart Association.

PY - 1986/12

Y1 - 1986/12

N2 - The nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79 has been determined. The deduced amino acid sequence of the M1 protein indicates that it contains 248 amino acids of which 243 are identical in the B/Lee/40 M, protein. A second overlapping open reading frame with a maximum coding region of 195 amino acids has also been maintained in the 39 years separating the two isolates. The deduced amino acid sequence of the second coding region displays 86% homology with the comparable B/Lee/40 sequence (27 changes). The conservation of the second open reading frame suggests that this region is important in the replicative cycle of influenza B viruses.

AB - The nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79 has been determined. The deduced amino acid sequence of the M1 protein indicates that it contains 248 amino acids of which 243 are identical in the B/Lee/40 M, protein. A second overlapping open reading frame with a maximum coding region of 195 amino acids has also been maintained in the 39 years separating the two isolates. The deduced amino acid sequence of the second coding region displays 86% homology with the comparable B/Lee/40 sequence (27 changes). The conservation of the second open reading frame suggests that this region is important in the replicative cycle of influenza B viruses.

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JO - Virology

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Nucleotide sequence of RNA segment 7 of influenza B/Singapore/222/79: Maintenance of a second large open reading frame

Abstract

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