Abstract
An analysis of the aminoacylation kinetics of unmodified yeast tRNA Phe mutants revealed that five single-stranded nucleotides are important for its recognition by yeast phenylalanyl-tRNA synthetase, provided they were positioned correctly in a properly folded tRNA structure. When four other tRNAs were changed to have these five nucleotides, they became near-normal substrates for the enzyme.
Original language | English (US) |
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Pages (from-to) | 1363-1366 |
Number of pages | 4 |
Journal | Science |
Volume | 243 |
Issue number | 4896 |
DOIs | |
State | Published - 1989 |
ASJC Scopus subject areas
- General