Numeric modeling of the cardiovascular system with a left ventricular assist device

Jianhua Zhou, Guy P. Armstrong, Alexander L. Medvedev, William A. Smith, Leonard A R Golding, James D. Thomas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A numeric model consisting of a lump-parameter cardiovascular system (CVS) model and a model for the Cleveland Clinic Implantable ventricular Assist System (IVAS) were developed. IVAS is a pulsatile rotary pump designed to augment the failing left ventricle. The hemodynamic interactions between CVS and IVAS under various physiologic and pathophysiologic conditions running at different speeds and the various IVAS control algorithms were investigated. The numeric modeling proved to be useful in predicting hemodynamic response of CVS to IVAS in various circumstances. Computer simulations also showed that IVAS resulted in normalization of cardiac output, especially in failing hearts at reduced pulse pressure.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalASAIO Journal
Issue number1
StatePublished - 1999

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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