Numeric modeling of the cardiovascular system with a left ventricular assist device

Jianhua Zhou; Guy P. Armstrong; Alexander L. Medvedev; William A. Smith; Leonard A R Golding; James D. Thomas

doi:10.1097/00002480-199901000-00019

Numeric modeling of the cardiovascular system with a left ventricular assist device

Jianhua Zhou, Guy P. Armstrong, Alexander L. Medvedev, William A. Smith, Leonard A R Golding, James D. Thomas^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A numeric model consisting of a lump-parameter cardiovascular system (CVS) model and a model for the Cleveland Clinic Implantable ventricular Assist System (IVAS) were developed. IVAS is a pulsatile rotary pump designed to augment the failing left ventricle. The hemodynamic interactions between CVS and IVAS under various physiologic and pathophysiologic conditions running at different speeds and the various IVAS control algorithms were investigated. The numeric modeling proved to be useful in predicting hemodynamic response of CVS to IVAS in various circumstances. Computer simulations also showed that IVAS resulted in normalization of cardiac output, especially in failing hearts at reduced pulse pressure.

Original language	English (US)
Pages (from-to)	83-89
Number of pages	7
Journal	ASAIO Journal
Volume	45
Issue number	1
DOIs	https://doi.org/10.1097/00002480-199901000-00019
State	Published - 1999

ASJC Scopus subject areas

Bioengineering
Biophysics
Biomedical Engineering
Biomaterials

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AU - Thomas, James D.

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Numeric modeling of the cardiovascular system with a left ventricular assist device

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