Numerical modeling of the failing ventricle: Impact of a nonpulsatile ventricular assist system

Jianhua Zhou*, Alexander L. Medvedev, William A. Smith, Leonard A R Golding, James D. Thomas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The Cleveland Clinic Implantable Ventricular Assist System (IVAS) is a nonpulsatile rotary pump designed to augment the failing left ventricle. The purpose of this study is to assess its impact on the cardiovascular system using computer simulation. We modified an existing numerical model (24 coupled differential equations, representing all cardiac chambers and systemic and pulmonary vasculature). The pump was added as an auxiliary chamber between the left ventricle (LV) and aorta with pressure-flow-speed characteristics derived from in vitro testing. Pump function was assessed for normal and failing ventricles at various pump speed. Computer simulations show that 1) numerical modeling is useful for predicting hemodynamic response to IVAS; 2) IVAS results in normalization of cardiac output, especially in failing hearts, though with reduced pulse pressure.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalComputers in Cardiology
Volume0
Issue number0
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

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