Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis

Bethany Sump, Jason H. Brickner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Nuclear pore proteins (Nups) interact with chromosomes to regulate gene expression and chromatin structure. A new study by Franks and colleagues (pp. 2222-2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how that process is altered by translocations to cause excess expression of developmental genes in leukemia.

Original languageEnglish (US)
Pages (from-to)2201-2203
Number of pages3
JournalGenes and Development
Volume31
Issue number22
DOIs
StatePublished - Nov 30 2017

Keywords

  • Acute myeloid leukemia
  • Histone 3 lys4 trimethylation
  • Nup98
  • Set1A
  • Transcription
  • Wdr82

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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