Nutrient regulation of cell cycle progression

Brenda L. Bohnsack*, Karen K. Hirschi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Cell replication is tightly controlled in normal tissues and aberrant during disease progression, such as in tumorigenesis. The replication of cells can be divided into four distinct phases: Gap 1 (G1), synthesis (S), gap 2 (G2), and mitosis (M). The progression from one phase to the next is intricately regulated and has many "checkpoints" that take into account cellular status and environmental cues. Among the modulators of cell cycle progression are specific nutrients, which function as energy sources or regulate the production and/or function of proteins needed to advance cells through a replicative cycle. In this review, we focus on the roles of specific nutrients (vitamin A, vitamin D, iron, folic acid, vitamin B12, zinc, and glucose) in the control of cell cycle progression and discuss how insights into the mechanisms by which these nutrients modulate this process can be and have been used to control aberrant cell growth in the treatment of prevalent pathologies.

Original languageEnglish (US)
Pages (from-to)433-453
Number of pages21
JournalAnnual Review of Nutrition
StatePublished - 2004
Externally publishedYes


  • DNA synthesis
  • Iron
  • Proliferation
  • Vitamin A
  • Vitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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