Nutrient sensing and the circadian clock

Clara Bien, Kathryn M Ramsey, Biliana Marcheva, Joseph Bass*

*Corresponding author for this work

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

The circadian system synchronizes behavioral and physiologic processes with daily changes in the external light-dark cycle, optimizing energetic cycles with the rising and setting of the sun. Molecular clocks are organized hierarchically, with neural clocks orchestrating the daily switch between periods of feeding and fasting, and peripheral clocks generating 24. h oscillations of energy storage and utilization. Recent studies indicate that clocks respond to nutrient signals and that a high-fat diet influences the period of locomotor activity under free-running conditions, a core property of the clock. A major goal is to identify the molecular basis for the reciprocal relation between metabolic and circadian pathways. Here the role of peptidergic hormones and macromolecules as nutrient signals integrating circadian and metabolic systems is highlighted.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume23
Issue number7
DOIs
StatePublished - Jul 1 2012

Fingerprint

Circadian Clocks
Food
Photoperiod
High Fat Diet
Solar System
Locomotion
Metabolic Networks and Pathways
Fasting
Hormones

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{e091fe6e2d8d46539f96f42271ab3785,
title = "Nutrient sensing and the circadian clock",
abstract = "The circadian system synchronizes behavioral and physiologic processes with daily changes in the external light-dark cycle, optimizing energetic cycles with the rising and setting of the sun. Molecular clocks are organized hierarchically, with neural clocks orchestrating the daily switch between periods of feeding and fasting, and peripheral clocks generating 24. h oscillations of energy storage and utilization. Recent studies indicate that clocks respond to nutrient signals and that a high-fat diet influences the period of locomotor activity under free-running conditions, a core property of the clock. A major goal is to identify the molecular basis for the reciprocal relation between metabolic and circadian pathways. Here the role of peptidergic hormones and macromolecules as nutrient signals integrating circadian and metabolic systems is highlighted.",
author = "Clara Bien and Ramsey, {Kathryn M} and Biliana Marcheva and Joseph Bass",
year = "2012",
month = "7",
day = "1",
doi = "10.1016/j.tem.2012.02.003",
language = "English (US)",
volume = "23",
pages = "312--318",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "7",

}

Nutrient sensing and the circadian clock. / Bien, Clara; Ramsey, Kathryn M; Marcheva, Biliana; Bass, Joseph.

In: Trends in Endocrinology and Metabolism, Vol. 23, No. 7, 01.07.2012, p. 312-318.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Nutrient sensing and the circadian clock

AU - Bien, Clara

AU - Ramsey, Kathryn M

AU - Marcheva, Biliana

AU - Bass, Joseph

PY - 2012/7/1

Y1 - 2012/7/1

N2 - The circadian system synchronizes behavioral and physiologic processes with daily changes in the external light-dark cycle, optimizing energetic cycles with the rising and setting of the sun. Molecular clocks are organized hierarchically, with neural clocks orchestrating the daily switch between periods of feeding and fasting, and peripheral clocks generating 24. h oscillations of energy storage and utilization. Recent studies indicate that clocks respond to nutrient signals and that a high-fat diet influences the period of locomotor activity under free-running conditions, a core property of the clock. A major goal is to identify the molecular basis for the reciprocal relation between metabolic and circadian pathways. Here the role of peptidergic hormones and macromolecules as nutrient signals integrating circadian and metabolic systems is highlighted.

AB - The circadian system synchronizes behavioral and physiologic processes with daily changes in the external light-dark cycle, optimizing energetic cycles with the rising and setting of the sun. Molecular clocks are organized hierarchically, with neural clocks orchestrating the daily switch between periods of feeding and fasting, and peripheral clocks generating 24. h oscillations of energy storage and utilization. Recent studies indicate that clocks respond to nutrient signals and that a high-fat diet influences the period of locomotor activity under free-running conditions, a core property of the clock. A major goal is to identify the molecular basis for the reciprocal relation between metabolic and circadian pathways. Here the role of peptidergic hormones and macromolecules as nutrient signals integrating circadian and metabolic systems is highlighted.

UR - http://www.scopus.com/inward/record.url?scp=84863113475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863113475&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2012.02.003

DO - 10.1016/j.tem.2012.02.003

M3 - Review article

VL - 23

SP - 312

EP - 318

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 7

ER -