Nutriome–metabolome relationships provide insights into dietary intake and metabolism

Joram M. Posma, Isabel Garcia-Perez, Gary Frost, Ghadeer S. Aljuraiban, Queenie Chan, Linda Van Horn, Martha Daviglus, Jeremiah Stamler, Elaine Holmes, Paul Elliott*, Jeremy K. Nicholson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dietary assessment traditionally relies on self-reported data, which are often inaccurate and may result in erroneous diet–disease risk associations. We illustrate how urinary metabolic phenotyping can be used as an alternative approach to obtain information on dietary patterns. We used two multipass 24 h dietary recalls, obtained on two occasions on average 3 weeks apart, paired with two 24 h urine collections from 1,848 US individuals; 67 nutrients influenced the urinary metabotype (metabolic phenotype) of 46 structurally identified metabolites characterized by 1H NMR spectroscopy. We investigated the stability of each metabolite over time and showed that the urinary metabolic profile is more stable within individuals than reported dietary patterns. The 46 metabolites accurately predicted healthy and unhealthy dietary patterns in a free-living US cohort, and these predictions were replicated in an independent UK cohort. We mapped these metabolites into a host-microbial metabolic network to identify key pathways and functions related to diet. These data can be used in future studies to evaluate how this set of diet-derived, stable, measurable bioanalytical markers is associated with disease risk. This knowledge may give new insights into biological pathways that characterize the shift from a healthy to an unhealthy metabolic phenotype and hence indicate entry points for prevention and intervention strategies.

Original languageEnglish (US)
Pages (from-to)426-436
Number of pages11
JournalNature Food
Volume1
Issue number7
DOIs
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Animal Science and Zoology
  • Food Science

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