Nutritional Therapy for High Blood Pressure: Final Report of a Four-Year Randomized Controlled Trial— The Hypertension Control Program

Rose Stamler, Jeremiah Stamler, Richard Grimm, Flora C. Gosch, Patricia Elmer, Alan Dyer, Reuben Berman, Joan Fishman, Nancy Van Heel, Jean Civinelli, Arline Mcdonald

Research output: Contribution to journalArticlepeer-review

261 Scopus citations

Abstract

A four-year trial assessed whether less severe hypertensives could discontinue antihypertensive drug therapy, using nutritional means to control blood pressure. Randomization was to three groups: group 1—discontinue drug therapy and reduce overweight, excess salt, and alcohol; group 2—discontinue drug therapy, with no nutritional program; or group 3—continue drug therapy, with no nutritional program. In groups 1 and 2 patients resumed drug therapy if pressure rose to hypertensive levels. Loss of at least 4.5 kg (10+ lb) was maintained by 30% of group 1, with a group mean loss of 1.8 kg (4 lb); sodium intake fell 36% and modest alcohol intake reduction was reported. At four years, 39% in group 1 remained normotensive without drug therapy, compared with 5% in group 2. Study findings demonstrated that nutritional therapy may substitute for drugs in a sizable proportion of hypertensives or, if drugs are still needed, can lessen some unwanted biochemical effects of drug treatment.

Original languageEnglish (US)
Pages (from-to)1484-1491
Number of pages8
JournalJAMA: The Journal of the American Medical Association
Volume257
Issue number11
DOIs
StatePublished - Mar 20 1987

ASJC Scopus subject areas

  • Medicine(all)

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