TY - JOUR
T1 - Nutritional therapy for high blood pressure. Final report of a four-year randomized controlled trial - The Hypertension Control Program
AU - Stamler, R.
AU - Stamler, Jeremiah
AU - Grimm, R.
AU - Gosch, F. C.
AU - Elmer, P.
AU - Dyer, Alan Richard
AU - Berman, R.
AU - Fishman, J.
AU - Van Heel, N.
AU - Civinelli, J.
PY - 1987/7/9
Y1 - 1987/7/9
N2 - A four-year trial assessed whether less severe hypertensives could discontinue antihypertensive drug therapy, using nutritional means to control blood pressure. Randomization was to three groups: group 1 - discontinue drug therapy and reduced overweight, excess salt, and alcohol; group 2 - discontinue drug therapy, with no nutritional program; or group 3 - continue drug therapy, with no nutritional program. In groups 1 and 2 patients resumed drug therapy if pressure rose to hypertensive levels. Loss of at least 4.5 kg (10 + lb) was maintained by 30% of group 1, with a group mean loss of 1.8 kg (4 lb); sodium intake fell 36% and modest alcohol intake reduction was reported. At four years, 39% in group 1 remained normotensive without drug therapy, compared with 5% in group 2. Study findings demonstrated that nutritional therapy may substitute for drugs in a sizable proportion of hypertensives or, if drugs are still needed, can lessen some unwanted biochemical effects of drug treatment.
AB - A four-year trial assessed whether less severe hypertensives could discontinue antihypertensive drug therapy, using nutritional means to control blood pressure. Randomization was to three groups: group 1 - discontinue drug therapy and reduced overweight, excess salt, and alcohol; group 2 - discontinue drug therapy, with no nutritional program; or group 3 - continue drug therapy, with no nutritional program. In groups 1 and 2 patients resumed drug therapy if pressure rose to hypertensive levels. Loss of at least 4.5 kg (10 + lb) was maintained by 30% of group 1, with a group mean loss of 1.8 kg (4 lb); sodium intake fell 36% and modest alcohol intake reduction was reported. At four years, 39% in group 1 remained normotensive without drug therapy, compared with 5% in group 2. Study findings demonstrated that nutritional therapy may substitute for drugs in a sizable proportion of hypertensives or, if drugs are still needed, can lessen some unwanted biochemical effects of drug treatment.
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U2 - 10.1001/jama.257.11.1484
DO - 10.1001/jama.257.11.1484
M3 - Article
C2 - 3546747
SN - 0098-7484
VL - 257
SP - 1484
EP - 1491
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
IS - 11
ER -