OARSI Clinical Trials Recommendations: Key analytic considerations in design, analysis, and reporting of randomized controlled trials in osteoarthritis

E. Losina*, J. Ranstam, J. E. Collins, T. J. Schnitzer, J. N. Katz

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

To highlight methodologic challenges pertinent to design, analysis, and reporting of results of randomized clinical trials in OA and offer practical suggestions to overcome these challenges.The topics covered in this paper include subject selection, randomization, approaches to handling missing data, subgroup analysis, sample size, and issues related to changing design mid-way through the study. Special attention is given to standardizing the reporting of results and economic analyses.Key findings include the importance of blinding and concealment, the distinction between superiority and non-inferiority trials, the need to minimize missing data, and appropriate analysis and interpretation of subgroup effects.Investigators may use the findings and recommendations advanced in this paper to guide design and conduct of randomized controlled trials of interventions for osteoarthritis.

Original languageEnglish (US)
Pages (from-to)677-685
Number of pages9
JournalOsteoarthritis and Cartilage
Volume23
Issue number5
DOIs
StatePublished - 2015

Keywords

  • Design
  • Economic evaluation
  • Missing data
  • Outcomes
  • Randomized controlled trials
  • Reporting

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

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