Abstract
Obesity has been associated with numerous pathologies such as diabetes and cardiovascular disease. More recently the incidence of certain cancers has been associated with obesity and overweight. This correlation is very well established for colon cancer and the aggressiveness of prostate cancer is significantly augmented in obese patients. Obesity is accompanied by an increase of the white adipose tissue (WAT) mass and adipokine (WAT cytokines) expression is greatly modified, leading to variation of plasmatic and local concentration. As adipose tissue is localized close to the urinary and gastrointestinal tracts these adipokines could play a major role in tumorogenesis and tumor growth in the prostate and colon. Since adiponectin and leptin are almost exclusively synthesized by WAT, we will focus on these adipokines as well as vascular endothelial growth factor (VEGF) and interleukin-6, secreted in large amounts by the WAT. Clinical and fundamental studies in vivo and in vitro suggest that these adipokines could interact with prostate and colon carcinogenesis, emphasizing the potential role of these adipokines as therapeutic targets against cancer in obese patients.
Translated title of the contribution | Obesity and colon and prostate cancer: Role of adipokines |
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Original language | French |
Pages (from-to) | 72-77 |
Number of pages | 6 |
Journal | Obesite |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2008 |
Keywords
- Adipokines
- Colon cancer
- Obesity
- Prostate cancer
ASJC Scopus subject areas
- Nutrition and Dietetics