TY - JOUR
T1 - Obesity 2021
T2 - Rejecting Old Misconceptions and Embracing a New Paradigm to Improve Outcomes
AU - Mangarelli, Caren
N1 - Funding Information:
The author thanks Dr. Kavitha Selvaraj for her thoughtful comments and suggestions on the draft version of the manuscript. In addition, Dr. Mangarelli thanks all of her clinical colleagues currently at Anne and Robert H. Lurie Children's Hospital's Wellness and Weight Management Program, and previously at Duke Children's Healthy Lifestyles Program, for their dedication and inspiration.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/7
Y1 - 2021/7
N2 - Despite the best efforts of many health care workers and increasing knowledge about the human energy regulatory system and dietary and exercise science, rates of obesity continue to rise. In the past 40 years, not a single country in the world has experienced a reduction in the prevalence of obesity. Over these same 40 years, treatment options such as medications, as well as bariatric and other surgical procedures, have continued to expand. Why then, are we not seeing more improvement in obesity outcomes? This commentary hypothesizes that it is due to a combination of factors. These factors include an individual's genetic predisposition combined with the modern obesogenic environment, an energy regulatory system that defends fat mass and fights loss, obesity not being seen as a disease state, and individual and societal weight bias. (Clin Ther. 2021;43:XXX–XXX)
AB - Despite the best efforts of many health care workers and increasing knowledge about the human energy regulatory system and dietary and exercise science, rates of obesity continue to rise. In the past 40 years, not a single country in the world has experienced a reduction in the prevalence of obesity. Over these same 40 years, treatment options such as medications, as well as bariatric and other surgical procedures, have continued to expand. Why then, are we not seeing more improvement in obesity outcomes? This commentary hypothesizes that it is due to a combination of factors. These factors include an individual's genetic predisposition combined with the modern obesogenic environment, an energy regulatory system that defends fat mass and fights loss, obesity not being seen as a disease state, and individual and societal weight bias. (Clin Ther. 2021;43:XXX–XXX)
KW - Energy regulatory system
KW - Obesity
KW - Obesogenic environment
KW - Outcomes
KW - Weight bias
UR - http://www.scopus.com/inward/record.url?scp=85108969311&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108969311&partnerID=8YFLogxK
U2 - 10.1016/j.clinthera.2021.06.002
DO - 10.1016/j.clinthera.2021.06.002
M3 - Comment/debate
C2 - 34210533
AN - SCOPUS:85108969311
SN - 0149-2918
VL - 43
SP - 1147
EP - 1153
JO - Clinical Therapeutics
JF - Clinical Therapeutics
IS - 7
ER -
