Obésité et cancers du côlon et de la prostate: Implication des adipokines

Translated title of the contribution: Obesity and colon and prostate cancer: Role of adipokines

I. Ben Sahra, Y. Le Marchand Brustel, J. F. Tanti, F. Bost*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Obesity has been associated with numerous pathologies such as diabetes and cardiovascular disease. More recently the incidence of certain cancers has been associated with obesity and overweight. This correlation is very well established for colon cancer and the aggressiveness of prostate cancer is significantly augmented in obese patients. Obesity is accompanied by an increase of the white adipose tissue (WAT) mass and adipokine (WAT cytokines) expression is greatly modified, leading to variation of plasmatic and local concentration. As adipose tissue is localized close to the urinary and gastrointestinal tracts these adipokines could play a major role in tumorogenesis and tumor growth in the prostate and colon. Since adiponectin and leptin are almost exclusively synthesized by WAT, we will focus on these adipokines as well as vascular endothelial growth factor (VEGF) and interleukin-6, secreted in large amounts by the WAT. Clinical and fundamental studies in vivo and in vitro suggest that these adipokines could interact with prostate and colon carcinogenesis, emphasizing the potential role of these adipokines as therapeutic targets against cancer in obese patients.

Translated title of the contributionObesity and colon and prostate cancer: Role of adipokines
Original languageFrench
Pages (from-to)72-77
Number of pages6
JournalObesite
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2008

Keywords

  • Adipokines
  • Colon cancer
  • Obesity
  • Prostate cancer

ASJC Scopus subject areas

  • Nutrition and Dietetics

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