Obesity and hyperlipidemia after heart transplantation

K. L. Grady, M. R. Costanzo-Nordin, L. S. Herold, S. Sriniavasan, R. Pifarre

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Body weight and serum lipids were retrospectively analyzed in 54 heart transplant recipients (mean age, 43 years; 80% male) who survived at least 1 year. Data were collected preoperatively and at 1, 2, and 3 years after heart transplantation. Analysis was performed using item frequencies, analysis of variance, and Pearson product moment correlations. From preoperatively to 1 year after heart transplantation, the weight of patients increased significantly from 100% to 117% of ideal body weight and did not decrease significantly over the first 3 postoperative years. Serum cholesterol and triglyceride values increased significantly from preoperative values of 175 mg/dl and 139 mg/dl, respectively, to 1-year postoperative values of more than 200 mg/dl (p = 0.01). Serum cholesterol, but not triglyceride levels, decreased significantly 3 years after surgery as compared with 1 year after surgery. In addition, overall serum cholesterol and triglyceride levels were higher in patients with coronary artery disease (248 mg/dl) than with dilated cardiomyopathy (207 mg/dl). Serum high-density lipoprotein remained within acceptable clinical levels (>35 mg/dl) during all 3 postoperative years. Serum low-density lipoproteins, elevated (139 mg/dl) for the first 2 postoperative years, fell to within the desirable range (<130 mg/dl) by the third posttransplant year. Heart function was normal throughout all 3 years. Six patients (11%) were given lipid-lowering medications after heart transplantation (mean, 25 postoperative months). In two of the six patients, treatment produced a sustained decrease in serum cholesterol and triglyceride (<200 mg/dl). Eight patients (15%) died between 1 and 3 years after transplantation of causes unrelated to allograft arteriopathy.

Original languageEnglish (US)
Pages (from-to)449-454
Number of pages6
JournalJournal of Heart and Lung Transplantation
Volume10
Issue number3
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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