The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study has provided an opportunity to assess the relative associations of maternal glycemia measured at an oral glucose tolerance test (mean 28 weeks gestation) and maternal body mass index with a range of adverse pregnancy outcomes, without many of the potential confounding factors seen in previous studies. The HAPO study confirmed independently significant associations between maternal BMI and birthweight >90th centile, frequency of primary cesarean section, neonatal hypoglycemia, neonatal hyperinsulinemia, preeclampsia, and neonatal adiposity. The combination of maternal obesity and gestational diabetes was associated with higher frequencies of adverse outcomes than either variable in isolation.
|Title of host publication
|Maternal Obesity and Pregnancy
|Springer-Verlag Berlin Heidelberg
|Number of pages
|Published - Oct 1 2012
ASJC Scopus subject areas
- General Medicine