Obesity-related metabolite profiles of black women spanning the epidemiologic transition

Lara R. Dugas; Elin Chorell; Jacob Plange-Rhule; Estelle V. Lambert; Guichan Cao; Richard S. Cooper; Brian T. Layden; Denise Scholten; Tommy Olsson; Amy Luke; Julia H. Goedecke

doi:10.1007/s11306-016-0960-6

Obesity-related metabolite profiles of black women spanning the epidemiologic transition

Lara R. Dugas^*, Elin Chorell, Jacob Plange-Rhule, Estelle V. Lambert, Guichan Cao, Richard S. Cooper, Brian T. Layden, Denise Scholten, Tommy Olsson, Amy Luke, Julia H. Goedecke

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 ± 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.

Original language	English (US)
Article number	45
Pages (from-to)	1-10
Number of pages	10
Journal	Metabolomics
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/s11306-016-0960-6
State	Published - Mar 1 2016

Keywords

African-origin
Amino acid profile
Obesity

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11306-016-0960-6

Cite this

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title = "Obesity-related metabolite profiles of black women spanning the epidemiologic transition",

abstract = "In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 ± 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.",

keywords = "African-origin, Amino acid profile, Obesity",

author = "Dugas, {Lara R.} and Elin Chorell and Jacob Plange-Rhule and Lambert, {Estelle V.} and Guichan Cao and Cooper, {Richard S.} and Layden, {Brian T.} and Denise Scholten and Tommy Olsson and Amy Luke and Goedecke, {Julia H.}",

note = "Funding Information: The authors would like to acknowledge the site-specific clinic staff members as well as the 2500 participants. LRD, EC, JG all conceived the idea, performed the analyses and wrote the manuscript. JPR, EVL, AL, LD, EC all collected the data and wrote the manuscript, EC, GC, LRD and DMS performed the analyses and BTL and RC wrote the manuscript. METS is funded in part by the National Institutes of Health (1R01DK80763). The metabolomics analysis is funded by Thuringsstiftelsen. Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

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doi = "10.1007/s11306-016-0960-6",

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T1 - Obesity-related metabolite profiles of black women spanning the epidemiologic transition

AU - Dugas, Lara R.

AU - Chorell, Elin

AU - Plange-Rhule, Jacob

AU - Lambert, Estelle V.

AU - Cao, Guichan

AU - Cooper, Richard S.

AU - Layden, Brian T.

AU - Scholten, Denise

AU - Olsson, Tommy

AU - Luke, Amy

AU - Goedecke, Julia H.

N1 - Funding Information: The authors would like to acknowledge the site-specific clinic staff members as well as the 2500 participants. LRD, EC, JG all conceived the idea, performed the analyses and wrote the manuscript. JPR, EVL, AL, LD, EC all collected the data and wrote the manuscript, EC, GC, LRD and DMS performed the analyses and BTL and RC wrote the manuscript. METS is funded in part by the National Institutes of Health (1R01DK80763). The metabolomics analysis is funded by Thuringsstiftelsen. Publisher Copyright: © 2016, Springer Science+Business Media New York.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 ± 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.

AB - In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 ± 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.

KW - African-origin

KW - Amino acid profile

KW - Obesity

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JF - Metabolomics

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Obesity-related metabolite profiles of black women spanning the epidemiologic transition

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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