TY - JOUR
T1 - Obliterative vasculopathy in systemic sclerosis
T2 - Endothelial precursor cells as novel targets for therapy
AU - Hinchcliff, Monique
AU - Varga, John
PY - 2007/1
Y1 - 2007/1
N2 - Systemic sclerosis (SSc) is associated with a progressive obliterative vasculopathy that accounts for serious clinical manifestations of the disease, and has, to date, no effective treatment. Vascular obliteration is accompanied by defective vasculogenesis due to impaired production, mobilization or function of bone marrow-derived vascular precursor cells. Statins enhance vascular precursor cell production in chronic cardiovascular diseases and may also have a therapeutic role in SSc. This paper evaluates the results from a recent open-label clinical trial of atorvastatin that support this notion. Larger controlled trials are now needed to critically evaluate the efficacy of statins for repairing vascular damage, enhancing vasculogenesis, and attenuating the burden of chronic vasculopathy in SSc.
AB - Systemic sclerosis (SSc) is associated with a progressive obliterative vasculopathy that accounts for serious clinical manifestations of the disease, and has, to date, no effective treatment. Vascular obliteration is accompanied by defective vasculogenesis due to impaired production, mobilization or function of bone marrow-derived vascular precursor cells. Statins enhance vascular precursor cell production in chronic cardiovascular diseases and may also have a therapeutic role in SSc. This paper evaluates the results from a recent open-label clinical trial of atorvastatin that support this notion. Larger controlled trials are now needed to critically evaluate the efficacy of statins for repairing vascular damage, enhancing vasculogenesis, and attenuating the burden of chronic vasculopathy in SSc.
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U2 - 10.1586/1744666X.3.1.11
DO - 10.1586/1744666X.3.1.11
M3 - Article
C2 - 20476946
AN - SCOPUS:33947265947
SN - 1744-666X
VL - 3
SP - 11
EP - 15
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
IS - 1
ER -