Abstract
Objectives: The objective of this study was to examine the association between high risk of obstructive sleep apnea (OSA) and subclinical atherosclerosis among South Asians in the United States. Design: A secondary analysis of cross-sectional data. Setting/Participants: A community-based cohort of 906 men and women participating in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Measurements: The Berlin Questionnaire was used to screen for OSA risk. Coronary artery calcium (CAC), common carotid artery intima-media thickness (IMT), and internal carotid artery IMT were used as measures of subclinical atherosclerosis. Results: The majority of participants (59%) with high OSA risk had CAC scores >0 compared with only 41% of participants with low OSA risk (P <.001). The high OSA risk group was older (P =.005), male (P =.04), had higher body mass index (P <.001) and had greater common carotid artery IMT (0.96 ± 0.27 mm) and internal carotid artery IMT (1.33 ± 0.42 mm) measurements. Snoring, sleep-disordered breathing (SDB), and high OSA risk were associated with subclinical atherosclerosis. However, only high OSA risk remained significant in multivariable models after controlling for demographic and clinical factors that included hypertension (HTN), obesity, diabetes, and dyslipidemia. Conclusions: High OSA risk, which includes overlapping comorbidities of HTN and obesity, was not associated with the time living in the US but was associated with subclinical atherosclerosis markers. These cardiovascular disease risk factors should include evaluation of the spectrum of SDB among all adults, including South Asian men and women.
Original language | English (US) |
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Pages (from-to) | 124-130 |
Number of pages | 7 |
Journal | Sleep Health |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2020 |
Funding
The work was supported by the National Institutes of Health (NHLBI RO1 HL093009). The data collection at University of California, San Francisco was also supported by NIH / NCRR UCSF-CTSI Grant Number UL1 RR024131. The first author was supported by a postdoctoral training grant (NIH T32 NR07088, Nursing Research Training in Symptom Management). R. D. developed the research question, conducted the review of literature, and wrote the manuscript draft. K. L. reviewed and edited the manuscript and assisted with statistical analyses. N. K. and A. K. designed the original study, collected the original data, and reviewed and edited the manuscript. The work was supported by the National Institutes of Health ( NHLBI RO1 HL093009 ). The data collection at University of California, San Francisco was also supported by NIH / NCRR UCSF-CTSI Grant Number UL1 RR024131 . The first author was supported by a postdoctoral training grant ( NIH T32 NR07088 , Nursing Research Training in Symptom Management). R. D. developed the research question, conducted the review of literature, and wrote the manuscript draft. K. L. reviewed and edited the manuscript and assisted with statistical analyses. N. K. and A. K. designed the original study, collected the original data, and reviewed and edited the manuscript.
Keywords
- Carotid intima-media thickness
- Coronary artery calcium
- Daytime sleepiness
- Hypertension
- Obesity
- Sleep-disordered breathing
ASJC Scopus subject areas
- Behavioral Neuroscience