Obstructive Sleep Apnoea correlates with C-reactive protein in obese Asian Indians

Bharat Bhushan, Randeep Guleria*, Anoop Misra, Ravinder M. Pandey, Kalpana Luthra, Naval Kishor Vikram

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: C-reactive protein (CRP), a marker of systemic inflammation, is an important predictor of future cardiovascular events. Whether the relationship of obstructive sleep apnoea (OSA) and CRP is independent of adiposity, needs to be investigated. Objective: To investigate the association of CRP levels with OSA in the obese and their comparison with lean subjects without OSA in Asian Indians residing in India. Methods and results: One hundred and eight obese subjects (62 treatment naïve obese subjects with OSA [cases] and 46 obese subjects without OSA [obese controls]) and 26 lean control subjects without OSA were studied. The subjects were without any apparent inflammatory disease. Obese subjects were matched for body mass index (BMI) and percentage body fat (%BF). Assessment included anthropometry, lipid profile and high sensitivity CRP (hs-CRP) levels. Mean hs-CRP levels were significantly higher in cases [(3.6 ± 2.0) mg/l than in obese controls (1.4 ± 1.4) mg/l, p < 0.001)] and in lean controls [(0.93 ± 0.71) mg/l, p > 0.05]. Conclusions: In this sample of Asian Indians, subjects with OSA had significantly higher CRP levels. These levels were directly proportional to the increase in severity of OSA and it was independent of adiposity. These observations have important implications for future cardiovascular risk in Asian Indians with OSA.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2009

Keywords

  • Asian Indians
  • C-reactive protein
  • Cardiovascular disease
  • Obesity
  • Obstructive sleep apnoea

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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