Occult lupus nephropathy: a correlated light, electron and immunofluorescent microscopic study

LANDY S. WEIS, LAUREN M. PACHMAN, ELIZABETH V. POTTER, P. R. LEWY, R. B. JENNINGS, P. B. HERDSON*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Renal biopsies obtained from four adolescent girls who developed symptomatic thrombocytopenia with serologicevidence of systemiclupus erythematosus, without clinical signs of renal involvement, showed glomerular disease by electron and immunofluorescent microscopy with light microscopic changes in two cases. Subsequently, three of the patients developed proteinuria, and repeat biopsies from all four showed appearances ranging from resolution to significant glomerulitis. The findings illustrate the variable patterns of occult glomerulitis in Iupus, and highlight the value of correlating light, electron and immunofluorescent studies in renal pathology.

Original languageEnglish (US)
Pages (from-to)401-419
Number of pages19
JournalHistopathology
Volume1
Issue number6
DOIs
StatePublished - Nov 1977

Keywords

  • glomerular deposits
  • lupus nephropathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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