Occult pulmonary synovial sarcoma confirmed by molecular techniques

Pedram Argani*, Frederic B. Askin, Paul Colombani, Elizabeth J. Perlman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We report a unique case of a minute, occult synovial sarcoma of the lung detected intraoperatively during a pneumothorax repair in a 17-year-old boy. No alternative primary site could be detected upon complete body imaging studies and physical examinations. The diagnosis was confirmed by demonstration of the characteristic SYT/SSX gene fusion by reverse transcriptase polymerase chain reaction (RT-PCR) performed upon RNA extracted from the paraffin block of the biopsy. This case demonstrates the utility of this technique in diagnostic pathology.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalPediatric and Developmental Pathology
Issue number1
StatePublished - 2000


  • Polymerase chain reaction
  • Reverse transcriptase
  • Synovial sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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