Ocular surface epithelial stem cells: Implications for ocular surface homeostasis

Leonard P.K. Ang, Donald T.H. Tan, Roger W. Beuerman, Robert M Lavker

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

The ocular surface is a complex biological continuum responsible for protection of the cornea and maintenance of corneal clarity. The precorneal tear film, neural innervation, and the protective blink reflex help sustain an environment favorable for epithelial cell layers. Epithelial cells are self-renewing; precursor cells, called stem cells, constantly differentiate into new ocular surface epithelium. Limbal stem cells are responsible for maintenance of the corneal epithelium, while the conjunctiva and possibly adnexal conjunctival structures are renewed by conjunctival stem cells.

Original languageEnglish (US)
Title of host publicationDry Eye and Ocular Surface Disorders
PublisherCRC Press
Pages225-246
Number of pages22
ISBN (Electronic)9780849378201
ISBN (Print)9780824747022
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • Medicine(all)

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