TY - GEN
T1 - ODEs model of foreign body reaction around peripheral nerve implanted electrode
AU - Di Pino, G.
AU - Formica, D.
AU - Lonini, L.
AU - Accoto, D.
AU - Benvenuto, A.
AU - Micera, S.
AU - Rossini, P. M.
AU - Guglielmelli, E.
PY - 2010
Y1 - 2010
N2 - The foreign body reaction that the neural tissue develops around an implanted electrode contributes to insulate the probe and enhances the electrical and mechanical mismatch. It is a complex interaction among cells and soluble mediators and the knowledge of this phenomenon can benefits of formal and analytical methods that characterize the mathematical models. This work offers a lumped component model, described by ordinary differential equations, that taking into account the main geometrical (size, shape, insertion angle) and chemical (coating surface) properties of the implant predict the thickness of the fibrotic capsule in a time frame when the reaction stabilizes. This tool allows to evaluate different hypothetical solutions for accounting the tissue-electrode mismatch.
AB - The foreign body reaction that the neural tissue develops around an implanted electrode contributes to insulate the probe and enhances the electrical and mechanical mismatch. It is a complex interaction among cells and soluble mediators and the knowledge of this phenomenon can benefits of formal and analytical methods that characterize the mathematical models. This work offers a lumped component model, described by ordinary differential equations, that taking into account the main geometrical (size, shape, insertion angle) and chemical (coating surface) properties of the implant predict the thickness of the fibrotic capsule in a time frame when the reaction stabilizes. This tool allows to evaluate different hypothetical solutions for accounting the tissue-electrode mismatch.
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UR - http://www.scopus.com/inward/citedby.url?scp=78650843401&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2010.5626825
DO - 10.1109/IEMBS.2010.5626825
M3 - Conference contribution
C2 - 21096377
AN - SCOPUS:78650843401
SN - 9781424441235
T3 - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
SP - 1543
EP - 1546
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -