Oestrogen receptor expression in normal breast epithelium

S. A. Khan*, M. A.M. Rogers, K. K. Khurana, J. F.M. Siddiqui

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Higher levels of oestrogen receptor (ER) expression in normal breast epithelium may compound the increase in breast cancer risk seen with prolonged estrogen exposure. In prior studies, we have used immunohistochemical ER assays on fresh frozen samples of benign breast tissue. Future studies will be more feasible on paraffin-embedded samples, and newer, more sensitive antibodies are now available. We examined 30 samples of paraffin-embedded breast epithelium from postmenopausal women with two antibodies, 6F11 and TE111. We find that the median labelling indices for ER are significantly higher using these antibodies, compared with previous results. The threshold for ER positivity will, therefore, have to be reset in future studies, since there are still many issues that remain to be resolved in this area. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)27-28
Number of pages2
JournalEuropean Journal of Cancer
Volume36
Issue numberSUPPL. 4
DOIs
StatePublished - 2000

Keywords

  • Breast cancer risk
  • Normal breast
  • Oestrogen receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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