Off-Label studies on anakinra in dermatology: a review

Kyle Tegtmeyer, Giancarlo Atassi, Jeffrey Zhao, Nolan J. Maloney, Peter A. Lio*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Purpose: Anakinra (Kineret®) is an interleukin-1 receptor antagonist (IL-1Ra) FDA approved for use in rheumatoid arthritis and in neonatal-onset multisystem inflammatory disease (NOMID). It has been used off-label for a variety of dermatologic conditions. A review of the available studies and cases of these off-label uses would be valuable to the dermatologist considering alternative treatments for these oftentimes poorly studied conditions. Materials and methods: The PubMed/MEDLINE, EMBASE, Scopus, and databases were searched with the term ‘anakinra.’ Results were manually screened to identify published data on off-label uses of anakinra in dermatologic conditions and systemic conditions with prominent dermatologic manifestations. Results: Anakinra appears to show efficacy for numerous dermatologic conditions, with the strongest evidence for hidradenitis suppurativa, Bechet’s disease, Muckle-Wells syndrome, and SAPHO syndrome. Case reports and case series data are available for numerous other dermatologic conditions. Conclusion: Anakinra is a potential option for patients with certain difficult-to-treat dermatologic diseases, given its relatively benign adverse effect profile and its effectiveness in a wide array of conditions. Overall, anakinra appears to be a promising option in the treatment of numerous dermatologic inflammatory conditions refractory to first line therapies, but further and higher-quality data is needed to clarify its therapeutic role.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalJournal of Dermatological Treatment
Issue number1
StatePublished - 2022


  • Anakinra
  • FDA
  • IL-1
  • Kineret
  • inflammation
  • off-label

ASJC Scopus subject areas

  • Dermatology


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