Olfactory input is critical for sustaining odor quality codes in human orbitofrontal cortex

Keng Nei Wu*, Bruce K. Tan, James D. Howard, David B. Conley, Jay A. Gottfried

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral and chronic rhinosinusitis, but how the brain encodes and maintains odor information under such circumstances remains poorly understood. Here we combined functional magnetic resonance imaging (fMRI) with multivariate (pattern-based) analyses and psychophysical approaches to show that a 7-d period of olfactory deprivation induces reversible changes in odor-evoked fMRI activity in piriform cortex and orbitofrontal cortex (OFC). Notably, multivoxel ensemble codes of odor quality in OFC became decorrelated after deprivation, and the magnitude of these changes predicted subsequent olfactory perceptual plasticity. Our findings suggest that transient changes in these key olfactory brain regions are instrumental in sustaining odor perception integrity in the wake of disrupted sensory input.

Original languageEnglish (US)
Pages (from-to)1313-1319
Number of pages7
JournalNature Neuroscience
Volume15
Issue number9
DOIs
StatePublished - Sep 1 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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