Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles

David A. Giljohann, Dwight S. Seferos, Pinal C. Patel, Jill E. Millstone, Nathaniel L. Rosi, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

477 Scopus citations


The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

Original languageEnglish (US)
Pages (from-to)3818-3821
Number of pages4
JournalNano letters
Issue number12
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


Dive into the research topics of 'Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles'. Together they form a unique fingerprint.

Cite this