Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles

David A. Giljohann, Dwight S. Seferos, Pinal C. Patel, Jill E. Millstone, Nathaniel L. Rosi, Chad A Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticle

417 Scopus citations

Abstract

The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

Original languageEnglish (US)
Pages (from-to)3818-3821
Number of pages4
JournalNano Letters
Volume7
Issue number12
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Giljohann, D. A., Seferos, D. S., Patel, P. C., Millstone, J. E., Rosi, N. L., & Mirkin, C. A. (2007). Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. Nano Letters, 7(12), 3818-3821. https://doi.org/10.1021/nl072471q