Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles

David A. Giljohann; Dwight S. Seferos; Pinal C. Patel; Jill E. Millstone; Nathaniel L. Rosi; Chad A. Mirkin

doi:10.1021/nl072471q

Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles

David A. Giljohann, Dwight S. Seferos, Pinal C. Patel, Jill E. Millstone, Nathaniel L. Rosi, Chad A. Mirkin^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

525 Scopus citations

Abstract

The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

Original language	English (US)
Pages (from-to)	3818-3821
Number of pages	4
Journal	Nano letters
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/nl072471q
State	Published - Dec 2007

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics
Mechanical Engineering
Bioengineering
General Materials Science

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10.1021/nl072471q

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title = "Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles",

abstract = "The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.",

author = "Giljohann, {David A.} and Seferos, {Dwight S.} and Patel, {Pinal C.} and Millstone, {Jill E.} and Rosi, {Nathaniel L.} and Mirkin, {Chad A.}",

year = "2007",

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AU - Giljohann, David A.

AU - Seferos, Dwight S.

AU - Patel, Pinal C.

AU - Millstone, Jill E.

AU - Rosi, Nathaniel L.

AU - Mirkin, Chad A.

PY - 2007/12

Y1 - 2007/12

N2 - The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

AB - The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

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Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles

Abstract

ASJC Scopus subject areas

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