Omental mesenteric myxoid hamartoma, a subtype of inflammatory myofibroblastic tumor? Considerations based on the histopathological evaluation of four cases

K. Ludwig, R. Alaggio*, P. Dall’Igna, E. Lazzari, E. S.G. d’Amore, P. M. Chou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Omental mesenteric myxoid hamartoma (OMH) is a distinctive myxoid lesion of infancy, characterized by a benign clinical behavior. In the current World Health Organization (WHO) classification of soft tissue tumors, it is considered as part of the morphologic spectrum of inflammatory myofibroblastic tumors (IMT), but this relationship with IMT is still subject to debate. Four lesions with histologic features of OMH occurring in newborns and toddlers are described and compared with classic, ALK-positive IMT. All OMH showed a peculiar dot-like immunostaining for ALK, which, in one of the cases, was cytogenetically found to be associated with an inversion of the ALK gene. While OMHs were positive for smooth muscle actin (SMA), desmin, WT1, podoplanin, and cytokeratins (CAM5.2 and AE1-3), IMT were consistently positive only for SMA (10 cases). ALK-1 displayed cytoplasmic staining in IMT and characteristic paranuclear dot-like staining in OMH.

Original languageEnglish (US)
Pages (from-to)741-747
Number of pages7
JournalVirchows Archiv
Volume467
Issue number6
DOIs
StatePublished - Dec 1 2015

Keywords

  • Inflammatory fibrosarcoma
  • Inflammatory myofibroblastic tumor
  • Myofibroblast
  • Omental myxoid hamartomas of the peritoneum
  • Peritoneal tumors
  • Submesothelial tissue
  • Subserosal cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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