On-chip synthesis and label-free assays of oligosaccharide arrays

Lan Ban*, Milan Mrksich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Sugar coated: A new strategy for solid-support oligosaccharide array synthesis and direct SAMDI-TOF (self-assembled monolayers for matrix-assisted laser desorption-ionization time-of-flight) mass spectrometry detection of the synthesis process is reported (see scheme). It incorporates an on-chip ligand array synthesis, a label-free detection method, and direct application to an enzymatic assay. (Chemical Equation).

Original languageEnglish (US)
Pages (from-to)3396-3399
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number18
DOIs
StatePublished - Apr 21 2008

Keywords

  • Biochips
  • Enzymes
  • Glycosides
  • Mass spectrometry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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