Imaging of cardiac perfusion with MR is a challenging area of research especially due to the motion of the heart and limited time of data acquisition. Compressed sensing is a popular signal estimation method recently adopted by researchers in MRI which can improve the spatial and/or temporal resolution of the acquired images by reducing the number of necessary samples for image reconstruction. This paper focuses on performance of temporal regularization with total variation and wavelets in compressed sensing. The impact of the choice of regularization parameters on the image quality and the temporal variation of intensity in region of interests (ROIs) are discussed. It is found that selecting the regularization parameter so as to optimize the quality of the reconstructed image sequence as a whole, leads to erroneous reconstruction of certain regions due to over regularization.