On the advancement of polymeric bicontinuous nanospheres toward biomedical applications

Sean D. Allen, Sharan Bobbala, Nicholas B. Karabin, Evan A. Scott*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Self-assembled soft nanocarriers that are capable of simultaneous encapsulation of both lipophilic and water soluble payloads have significantly enhanced controlled delivery applications in biomedicine. These nanoarchitectures, such as liposomes, polymersomes and cubosomes, are primarily composed of either amphiphilic polymers or lipids, with the polymeric variants generally possessing greater stability and control over biodistribution and bioresponsive release. Polymersomes have long demonstrated such advantages over their lipid analogs, liposomes, but only recently have bicontinuous nanospheres emerged as a polymeric cubic phase alternative to lipid cubosomes. In this review, we summarize the current state of the field for bicontinuous nanosphere formulation and characterization and suggest future directions for this nascent delivery platform as it is adopted for biomedical applications.

Original languageEnglish (US)
Pages (from-to)321-338
Number of pages18
JournalNanoscale Horizons
Issue number2
StatePublished - Mar 2019

ASJC Scopus subject areas

  • General Materials Science


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