On the mechanism of the effects of potassium restriction on blood pressure and renal sodium retention

Ian W. Gallen, Robert M. Rosa*, Daisy Y. Esparaz, James B. Young, Gary L. Robertson, Daniel Batlle, Franklin H. Epstein, Lewis Landsberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Dietary potassium restriction increases sodium and chloride retention, whereas potassium administration promotes both diuresis and natriuresis. In epidemiologic and clinical studies, potassium intake is inversely related to blood pressure and is lower in blacks than in whites. The present studies examined the mechanism by which potassium restriction fosters sodium conservation and the impact of race on this response. Twenty-one healthy black and white men and women ingested an isocaloric, potassium-restricted diet (20 mmol/d) containing 180 mmol/d of sodium with and without a potassium supplement (80 mmol/d) for 9 days on two occasions. Additionally, eight of these subjects ingested the same diets for 3 days followed bY a water load to determine free water clearance before and during the early phase of dietary potassium restriction. During potassium restriction mean arterial pressure (MAP) derived from 24-hour blood pressure measurements was higher (85.7 ± 1.6 mm Hg v 82.0 ± 1.3 mm Hg; P < 0.001), cumulative sodium excretion lower (984 ± 59 mmol/d V 1,256 ± 58 mmol/d; P < 0.001), and weight greater (71.1 ± 2.1 kg v 69.3 ± 2.2 kg; P < 0.001). Blacks displayed no greater increase in MAP, although they excreted less sodium overall and less potassium on the potassium-supplemented diet. After a water load, minimum urine osmolality (Uosm) was lower (53.0 ± 3.0 mOsm/L v 65.6 ± 3.5 mOsm/L; P = 0.01) and free water clearance greater (4.44 ± 0.59 mL/min v 3.72 ± 0.58 mL/min; P = 0.009) during potassium restriction. In conclusion, in healthy, normotensive subjects, potassium restriction was associated with an increase in blood pressure and volume expansion effected by increased renal sodium and chloride retention. Potassium restriction was also associated with increased free water clearance and enhanced diluting capacity consistent with augmentation of Na+, K+:2Cl- cotransporter activity n the thick ascending limb of Henle. This mechanism may play an important role in the renal adaptation required for potassium conservation, but at the expense of sodium chloride retention and an elevation in blood pressure.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalAmerican Journal of Kidney Diseases
Issue number1
StatePublished - Jan 1998


  • Blood pressure
  • Chloride excretion
  • Dietary potassium
  • Race
  • Sodium excretion
  • Water excretion

ASJC Scopus subject areas

  • Nephrology


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