Oncocytic papillary cystadenoma with prominent mucinous differentiation of parotid gland: A case report

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5 Scopus citations

Abstract

We describe the case of an oncocytic papillary cystadenoma with mucinous differentiation of the parotid gland in a 64-year-old male. Histologically, the tumor exhibited distinctive areas of intracystic papillary growth pattern with microcystic and macrocystic spaces containing mucinous secretions and small crystals. The cyst wall and papillary fronds were lined by oncocytic admixed with numerous mucocytes. Lymphoid tissue and invasive features were not identified. The tumor showed strong expression of CK7 and mammaglobin in oncocytes, and BRST-2 and MUC4 in mucocytes. p63, ER, PR, SOX10, DOG-1, and S100 stains were negative. No rearrangement of the MAML2 gene region or ETV6-NTRK3 fusion transcript was detected. The diagnosis of oncocytic papillary tumor with prominent mucinous differentiation is particularly problematic owing to the large number of potential mimics and should prompt consideration of appropriate molecular studies.

Original languageEnglish (US)
Pages (from-to)1310-1314
Number of pages5
JournalPathology Research and Practice
Volume213
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • Oncocytic papillary cystadenoma
  • Parotid gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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