Oncogenes and the initiation and maintenance of tumorigenesis

Dean W. Felsher*, Constadina Arvanitis, Pavan Bendapudi, Pavan Bachireddy

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Cancer is a complex and multistep process whereby an individual cell acquires a series of mutant gene products culminating in a spectrum of pathophysiologic features including relentless proliferation, growth, blocked differentiation, the inappropriate induction of angiogenesis, tissue invasion, and loss of genomic stability. Given the genetic and biologic complexity of tumorigenesis, it is perhaps surprising that there are circumstances when cancer can be reversed through the repair or inactivation of individual mutant genes. However, recent experiments in transgenic mouse models and clinical results using new pharmacological agents demonstrate that cancer can be treated through the targeted repair and/or inactivation of specific oncogenes. Hence, cancers appear to be dependent upon particular oncogenes to maintain their neoplastic properties, thus exhibiting the phenomena tumor maintenance or oncogene addiction.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Human Cancer
PublisherSpringer New York
Pages143-157
Number of pages15
ISBN (Electronic)9781597454582
ISBN (Print)9781934115183
DOIs
StatePublished - Jan 1 2016

Keywords

  • Oncogene signaling pathways
  • Oncogenes
  • Targeted oncogenes
  • Tumorigenesis

ASJC Scopus subject areas

  • Medicine(all)

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