Oncogenes, protooncogenes, and tumor suppressor genes in acute myelogenous leukemia

Nobuko Hijiya, Alan M. Gewirtz*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In recent years, our understanding of normal human hematopoiesis has expanded greatly. We have increased our knowledge of regulatory growth factors, the receptors through which they act, and the secondary messengers involved in transducing the growth/differentiation signals from the cytoplasmic membrane to the nucleus. This knowledge has revealed potential mechanisms for inducing the neoplastic transformation of hematopoietic cells. This applies in particular to the role of viral oncogenes and cellular protooncogenes and, more recently, to the role of tumor suppressor genes. Protooncogenes are intimately involved in the processes of cell proliferation and differentiation. Therefore, any amplification, mutation, structural alteration, or change in transcriptional regulation of protooncogenes might lead to or be associated with induction of the malignant phenotype. Based on the importance of these genes in leukemogenesis and the maintenance of the malignant phenotype, it seems reasonable to hypothesize that targeted disruption of leukemogenic genes may be of therapeutic value.

Original languageEnglish (US)
Pages (from-to)101-112
Number of pages12
JournalJournal of pediatric hematology/oncology
Volume17
Issue number2
DOIs
StatePublished - May 1995

Keywords

  • Acute myelogenous leukemia
  • Antisense
  • Growth Factor
  • Hematopoiesis
  • Oncogenes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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