TY - JOUR
T1 - Osteomalacia oncogênica
T2 - A perda de fosfatemia pode ser a chave para evitar o diagnóstico incorreto
AU - Chang, Claudia V.
AU - Conde, Sandro J.
AU - Luvizotto, Renata A.M.
AU - Nunes, Vânia S.
AU - Bonates, Milla C.
AU - Felicio, Andre C.
AU - Lindsey, Susan C.
AU - Moraes, Flávia H.
AU - Tagliarini, José V.
AU - Mazeto, Glaucia M.F.S.
AU - Kopp, Peter
AU - Nogueira, Célia R.
PY - 2012/11
Y1 - 2012/11
N2 - Diagnosing oncogenic osteomalacia is still a challenge. The disorder is characterized by osteomalacia caused by renal phosphate wasting and low serum concentration of 1,25-dihydroxyvitamin D3 occurring in the presence of a tumor that produces high levels of fibroblast growth factor 23. However, it is possible that the disease is much more misdiagnosed than rare. We present the case of a 42-year-old man with a long-term history of undiagnosed progressive muscle weakness. His laboratory results mainly showed low serum phosphate. Surgical removal of a nasal hemangiopericytoma that had been diagnosed five years earlier, brought him to a symptom-free condition. Even though knowing the underlying etiology would explain his osteomalacia, the patient sought medical help from countless physicians for five consecutive years, and only after adequate treatment a rewarding outcome was achieved.
AB - Diagnosing oncogenic osteomalacia is still a challenge. The disorder is characterized by osteomalacia caused by renal phosphate wasting and low serum concentration of 1,25-dihydroxyvitamin D3 occurring in the presence of a tumor that produces high levels of fibroblast growth factor 23. However, it is possible that the disease is much more misdiagnosed than rare. We present the case of a 42-year-old man with a long-term history of undiagnosed progressive muscle weakness. His laboratory results mainly showed low serum phosphate. Surgical removal of a nasal hemangiopericytoma that had been diagnosed five years earlier, brought him to a symptom-free condition. Even though knowing the underlying etiology would explain his osteomalacia, the patient sought medical help from countless physicians for five consecutive years, and only after adequate treatment a rewarding outcome was achieved.
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U2 - 10.1590/S0004-27302012000800018
DO - 10.1590/S0004-27302012000800018
M3 - Article
C2 - 23295300
AN - SCOPUS:84872362680
VL - 56
SP - 570
EP - 573
JO - Archives of endocrinology and metabolism
JF - Archives of endocrinology and metabolism
SN - 2359-3997
IS - 8
ER -
