Oncogenic osteomalacia: Loss of hypophosphatemia might be the key to avoid misdiagnosis

Claudia V. Chang; Sandro J. Conde; Renata A.M. Luvizotto; Vânia S. Nunes; Milla C. Bonates; Andre C. Felicio; Susan C. Lindsey; Flávia H. Moraes; José V. Tagliarini; Glaucia M.F.S. Mazeto; Peter Kopp; Célia R. Nogueira

doi:10.1590/S0004-27302012000800018

Oncogenic osteomalacia: Loss of hypophosphatemia might be the key to avoid misdiagnosis

Claudia V. Chang, Sandro J. Conde, Renata A.M. Luvizotto, Vânia S. Nunes, Milla C. Bonates, Andre C. Felicio, Susan C. Lindsey, Flávia H. Moraes, José V. Tagliarini, Glaucia M.F.S. Mazeto, Peter Kopp, Célia R. Nogueira

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8 Scopus citations

Abstract

Diagnosing oncogenic osteomalacia is still a challenge. The disorder is characterized by osteomalacia caused by renal phosphate wasting and low serum concentration of 1,25-dihydroxyvitamin D3 occurring in the presence of a tumor that produces high levels of fibroblast growth factor 23. However, it is possible that the disease is much more misdiagnosed than rare. We present the case of a 42-year-old man with a long-term history of undiagnosed progressive muscle weakness. His laboratory results mainly showed low serum phosphate. Surgical removal of a nasal hemangiopericytoma that had been diagnosed five years earlier, brought him to a symptom-free condition. Even though knowing the underlying etiology would explain his osteomalacia, the patient sought medical help from countless physicians for five consecutive years, and only after adequate treatment a rewarding outcome was achieved.

Original language	English (US)
Pages (from-to)	570-573
Number of pages	4
Journal	Arquivos brasileiros de endocrinologia e metabologia
Volume	56
Issue number	8
DOIs	https://doi.org/10.1590/S0004-27302012000800018
State	Published - Nov 2012

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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10.1590/S0004-27302012000800018

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Chang, C. V., Conde, S. J., Luvizotto, R. A. M., Nunes, V. S., Bonates, M. C., Felicio, A. C., Lindsey, S. C., Moraes, F. H., Tagliarini, J. V., Mazeto, G. M. F. S., Kopp, P., & Nogueira, C. R. (2012). Oncogenic osteomalacia: Loss of hypophosphatemia might be the key to avoid misdiagnosis. Arquivos brasileiros de endocrinologia e metabologia, 56(8), 570-573. https://doi.org/10.1590/S0004-27302012000800018

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title = "Oncogenic osteomalacia: Loss of hypophosphatemia might be the key to avoid misdiagnosis",

abstract = "Diagnosing oncogenic osteomalacia is still a challenge. The disorder is characterized by osteomalacia caused by renal phosphate wasting and low serum concentration of 1,25-dihydroxyvitamin D3 occurring in the presence of a tumor that produces high levels of fibroblast growth factor 23. However, it is possible that the disease is much more misdiagnosed than rare. We present the case of a 42-year-old man with a long-term history of undiagnosed progressive muscle weakness. His laboratory results mainly showed low serum phosphate. Surgical removal of a nasal hemangiopericytoma that had been diagnosed five years earlier, brought him to a symptom-free condition. Even though knowing the underlying etiology would explain his osteomalacia, the patient sought medical help from countless physicians for five consecutive years, and only after adequate treatment a rewarding outcome was achieved.",

author = "Chang, {Claudia V.} and Conde, {Sandro J.} and Luvizotto, {Renata A.M.} and Nunes, {V{\^a}nia S.} and Bonates, {Milla C.} and Felicio, {Andre C.} and Lindsey, {Susan C.} and Moraes, {Fl{\'a}via H.} and Tagliarini, {Jos{\'e} V.} and Mazeto, {Glaucia M.F.S.} and Peter Kopp and Nogueira, {C{\'e}lia R.}",

year = "2012",

month = nov,

doi = "10.1590/S0004-27302012000800018",

language = "English (US)",

volume = "56",

pages = "570--573",

journal = "Arquivos brasileiros de endocrinologia e metabologia",

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Chang, CV, Conde, SJ, Luvizotto, RAM, Nunes, VS, Bonates, MC, Felicio, AC, Lindsey, SC, Moraes, FH, Tagliarini, JV, Mazeto, GMFS, Kopp, P & Nogueira, CR 2012, 'Oncogenic osteomalacia: Loss of hypophosphatemia might be the key to avoid misdiagnosis', Arquivos brasileiros de endocrinologia e metabologia, vol. 56, no. 8, pp. 570-573. https://doi.org/10.1590/S0004-27302012000800018

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T2 - Loss of hypophosphatemia might be the key to avoid misdiagnosis

AU - Chang, Claudia V.

AU - Conde, Sandro J.

AU - Luvizotto, Renata A.M.

AU - Nunes, Vânia S.

AU - Bonates, Milla C.

AU - Felicio, Andre C.

AU - Lindsey, Susan C.

AU - Moraes, Flávia H.

AU - Tagliarini, José V.

AU - Mazeto, Glaucia M.F.S.

AU - Kopp, Peter

AU - Nogueira, Célia R.

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Y1 - 2012/11

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Oncogenic osteomalacia: Loss of hypophosphatemia might be the key to avoid misdiagnosis

Abstract

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