Oncologic Outcomes of Primary Lymphoma of Bone in Adults

Valerae O. Lewis*, Gregory Primus, John Anastasi, Dorota Doherty, Anthony G. Montag, Terrance D. Peabody, Michael A. Simon

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

A retrospective analysis of adult patients who had lymphomatous involvement of bone was done to evaluate the prognostic factors and the oncologic outcome. Between 1984 and 1994, 28 patients (nine women and 19 men) were diagnosed with lymphoma of bone. The median age was 45 years (range, 23-76 years). The median followup was 40.3 months (range, 0.5 months-15.8 years). Eighteen patients (64%) were classified as having Stage IE disease, two patients (36%) were classified as having Stage II disease, and eight patients were classified as having Stage IV disease. Twenty-one of the lesions were classified as diffuse large B cell with multilobulated nuclei. Two patients had local recurrence. Three patients had osteonecrosis develop at the site of their radiation therapy. The 5-year Kaplan-Meier survival estimate was 57.8% (95% confidence interval range, 40.33-82.8). Statistically improved survival was seen in patients younger than 40 years and in patients with diffuse large B cell with multilobulated nuclei. Patients with primary lymphoma of bone did not have a statistically improved survival compared with patients with systemic disease. The results of the current study suggest that age at diagnosis and histologic subtypes are important prognostic factors; however, the diagnosis of primary lymphoma of bone does not confer improved prognosis.

Original languageEnglish (US)
Pages (from-to)90-97
Number of pages8
JournalClinical orthopaedics and related research
Issue number415
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Oncologic Outcomes of Primary Lymphoma of Bone in Adults'. Together they form a unique fingerprint.

Cite this